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| | 107 | LEAD PLAINTIFF: Case Filed: 2008-03-16 |
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Case Summary: Studies indicate that Celexa can increase the risk of birth defects when taken by pregnant women; the doses used in these studies were higher than normal therapy doses. Celexa is excreted in breast milk, and it may cause excessive sleepiness and/or weight loss in a nursing infant so it is not recommended that women breastfeed while taking Celexa. Celexa pphnIn February of 2006, the New England Journal of Medicine reported that babies exposed to antidepressants like Celexa in the last trimester were 6 times more likely to be born with PPHN than babies who were not exposed. According to the report, up to 12 newborns in 1,000 developed persistent pulmonary hypertension (PPH) after exposure to SSRI's during pregnancy, versus 1 to 2 newborns on average. Babies born with PPHN have abnormal blood flow through their heart and lungs, and their bodies are deprived of oxygen. This may cause organ failure in the brain and kidneys. About 20% of babies born with PPHN do not survive, and those that do may have long-term breathing problems. Animal studies using large doses of Celexa are reported to show adverse effects on embryo, fetal and postnatal development. There are no similar studies of pregnant woman, therefore, the note concludes, the drug "should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus." There is also a warning that neonates exposed to Celexa late in the third trimester have developed complications requiring prolonged hospital care, respiratory support and tube feedings. Case Detail: Celexa Linked to Birth Defect PPHN Celexa is a brand name for Citalopram, a Selective Serotonin Reuptake Inhibitor (SSRI). SSRIs work by raising or restoring serotonin levels and relieving depression. Celexa is used to treat patients with major depressive disorder and obsessive-compulsive disorder, though it is not FDA approved for this diagnosis. |
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